本期内容涵盖AI赋能的高通量功能基因组研究、AI在医疗领域的应用、骨关节炎、骨质疏松、先心病遗传学检测、胃肠癌分期及预后、精神病学研究新范式、儿童注意力缺陷多动症、生物可降解血管支架，不可成药靶点药物开发新策略等，作者来自中国、美国、德国、日本等国家的高水平研究机构，包括北京大学、清华大学、北京师范大学、上海交通大学、复旦大学、浙江大学、空军军医大学、美国哈佛大学医学院、美国印第安纳大学医学院、美国新泽西理工学院、德国国家癌症研究中心、日本医科大学附属医院等。共发表11篇文章，包括3篇Perspective，1篇Commentary，1篇Short Communication，2篇Research Article，4篇Review Article。

Perspective

Paradigm shift in psychiatric neuroscience: Multidimensional integrative theory

跨越维度转变精神病学研究的神经科学范式

Gong Z Q, Biswal B B, Zuo X N. Paradigm shift in psychiatric neuroscience: Multidimensional integrative theory. Med Plus. 2024; 1(2):100024. https://doi.org/10.1016/j.medp.2024.100024.

Harnessing the power of mosquito gut microbiome in disease control

利用蚊虫肠道菌群的力量进行疾病防控

Shi H, Cao Y, Cheng G. Harnessing the power of mosquito gut microbiome in disease control. Med Plus. 2024;1(2):100023. https://doi.org/10.1016/j.medp.2024.100023.

Peripheral vascular bioresorbable scaffolds: Past, present, and future

外周血管生物可吸收支架：过去、现在和未来

Gao Z, Jiang W, Ran F. Peripheral vascular bioresorbable scaffolds: Past, present, and future. Med Plus. 2024;1(2):100031. https://doi.org/10.1016/j.medp.2024.100031.

Commentary

A molecular glue for P53

P53 的分子胶水

Liu H K. A molecular glue for P53. Med Plus. 2024;1(2):100026. https://doi.org/10.1016/j.medp.2024.100026.

Short Communication

Difficult speech-on-speech recognition as a behavioral indicator in children with attention deficit hyperactivity disorder

儿童注意力缺陷多动症有无客观评估指标？（一项多中心联合，关于语音识别困难的研究）

Fan J, Liu Y, Wang S, et al. Difficult speech-on-speech recognition as a behavioral indicator in children with attention deficit hyperactivity disorder. Med Plus. 2024;1(2):100029. https://doi.org/10.1016/j.medp.2024.100029

Research Article

Targeting RIP3 inhibits osteoarthritis development by restoring anabolic-catabolic balance in the bone-cartilage unit

解锁骨关节炎治疗新钥匙——RIP3在软骨与软骨下骨中的双重作用

Cheng J, Wang C, Zhu J, et al. Targeting RIP3 inhibits osteoarthritis development by restoring anabolic-catabolic balance in the bone-cartilage unit. Med Plus. 2024;1(2):100032. https://doi.org/10.1016/j.medp.2024.100032.

Osteoblast-derived extracellular vesicles exert bone formation effects by WIF1-mediated regulation of mitophagy

成骨细胞外囊泡与WIF1结合，调控线粒体自噬，增强骨形成潜能

Gu Y, Zhao J, Wang J, et al. Osteoblast-derived extracellular vesicles exert bone formation effects by WIF1-mediated regulation of mitophagy. Med Plus. 2024;1(2):100033. https://doi.org/10.1016/j.medp.2024.100033.

Review Article

Progresses in genetic testing in congenital heart disease

遗传学检测在先天性心脏病中的最新应用进展

Gao H, Liu Y, Sheng W, et al. Progresses in genetic testing in congenital heart disease. Med Plus. 2024;1(2):100028. https://doi.org/10.1016/j.medp.2024.100028.

Tumor deposits in colorectal and gastric cancers

癌结节对胃肠癌患者预后及分期的影响

Yao R, Gao X, Yu J, et al. Tumor deposits in colorectal and gastric cancers. Med Plus. 2024;1(2):100025. https://doi.org/10.1016/j.medp.2024.100025.

Health research in the era of artificial intelligence: Advances in gene-editing study

AI赋能碱基尺度高通量功能基因组研究

Dai M, Li X, Zhang Q, et al. Health research in the era of artificial intelligence: Advances in gene-editing study. Med Plus. 2024,1(2):100027. https://doi.org/10.1016/j.medp.2024.100027.

Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant

大语言模型揭示通向人工智能医疗助理的发展路径

Yuan M, Bao P, Yuan J, et al. Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant. Med Plus. 2024;1(2):100030. https://doi.org/10.1016/j.medp.2024.100030.