1920 年代：梅奥诊所的 Russell Wilder 博士开发了用于治疗儿童癫痫的生酮饮食。结果令人瞩目。癫痫发作难以控制的儿童癫痫发作减少50%至90%。有些儿童甚至完全停止了癫痫发作。酮体能够改变大脑代谢。到1930年，这已成为标准治疗方法。成千上万的儿童成功接受了治疗。1938 年：苯妥英被发现——第一种抗癫痫药物。它不如生酮饮食有效，副作用严重，需要终身服用，但可以申请专利。制药公司积极进行市场推广。到1950年，生酮饮食的使用率下降了90%。这种饮食疗法基本上被人们遗忘，直到 20 世纪 90 年代，吉姆·亚伯拉罕的儿子查理患上了无法控制的癫痫。多种药物都无效。他每天发作数百次。阿布拉姆斯发现了梅奥诊所的旧研究。查理开始生酮饮食几天后，癫痫发作就完全停止了。阿布拉姆斯非常愤怒。为什么一开始没有提供这个方案？他于1994年创立了查理基金会，旨在推动生酮饮食研究。饮食习惯逐渐恢复，但它被列为“替代疗法”或“最后手段”。一线治疗方案？仍然是疗效较低的药物。我们在 1920 年就有了治愈方法。但我们放弃了它 70 年，因为药片比食物更有利可图。查理已经30年没有癫痫发作了。在长达70年的时间里，当这种治疗方法被“遗忘”时，有多少儿童遭受了痛苦？1920s: Dr. Russell Wilder at Mayo Clinic develops the ketogenic diet for pediatric epilepsy.The results are extraordinary. Children with uncontrollable seizures see 50-90% reduction. Some become completely seizure-free. Ketones change brain metabolism.By 1930, it's standard treatment. Thousands of children successfully treated.Then 1938: Phenytoin is discovered - the first pharmaceutical anti-seizure medication.It's less effective than ketogenic diet. Serious side effects. Requires lifetime prescribing. But it can be patented.Pharmaceutical companies market aggressively. By 1950, ketogenic diet use drops 90%.The diet is largely forgotten until the 1990s when Jim Abrahams' son Charlie develops uncontrollable epilepsy. Multiple medications fail. Hundreds of seizures daily.Abrahams discovers the old Mayo Clinic research. Within days of starting ketogenic diet, Charlie's seizures stop completely.Abrahams is furious. Why wasn't this offered first? He founds the Charlie Foundation in 1994 to promote ketogenic research.Slowly, the diet returns. But it's listed as "alternative therapy" or "last resort."First-line treatment? Still pharmaceutical drugs with lower efficacy.We had a cure in 1920. We abandoned it for 70 years because pills are more profitable than food.Charlie has been seizure-free for 30 years.How many children suffered during those 70 years when the treatment was "forgotten"?